In combination with an appropriate diagnostic test, the Cav-P1/3C R° FMDV vaccine may also serve as a marker vaccine to differentiate vaccinated from infected animals.Ĭanine adenovirus type 2 (CAV2) FMDV Foot-and-mouth disease Vaccination.Ĭopyright © 2018 The Author(s). This suggest that Cav-P1/3C R° FMDV vaccine may protect natural host species from FMD. Precautions Only vaccinate healthy animals. Annual revaccination with a single dose is recommended. All dogs over 12 weeks of age shoud initially receive one dose of Spectra® 9 and a second dose 2 to 3 weeks later. The results of the present study show that CAV2-based vector vaccines can express immunogenic FMDV antigens and offer protection against generalized FMD in GP. Puppies should be revaccinated every 2 to 3 weeks until at least 16 weeks of age. The Cav-P1/3C R° vaccine protected GP from generalized FMD to a similar extent as a high potency double-oil emulsion O 1 Manisa vaccine. GP were then used as an experimental model for the determination of the protection afforded by the Cav-P1/3C R° vaccine against challenge with the FMDV strain O 1 Manisa/Turkey/1969. A strong humoral immune response was elicited in guinea pigs (GP) following immunization with Cav-P1/3C R°, while administration of Cav-VP1 R° did not induce a satisfying antibody response in GP or mice. In the present study, recombinant canine adenovirus type 2 (CAV2)-based FMD vaccines, Cav-P1/3C R° and Cav-VP1 R°, respectively expressing the structural P1 precursor protein along with the non-structural 3C protein or expressing the structural VP1 protein of the FMDV strain O/FRA/1/2001, were evaluated as novel vaccines against FMD. Rabies: required > 16 weeks (Hawaii not required) DPP (Distemper. Current Vaccinations Required: Salon (Dog). The majority of the antigenic sites that induce protective immune responses are localized on the FMD virus (FMDV) capsid that is formed by four virus-encoded structural proteins, VP1 to VP4. For the vaccination of healthy, susceptible dogs and puppies as an aid in the reduction of diseases caused by Canine Distemper, Canine Adenovirus Types 1 & 2, Parainfluenza and Parvovirus. Rabies tags in lieu of veterinary records. Vaccination is a key element in the control of foot-and-mouth disease (FMD).
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